World
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Even moderate drinking in pregnancy may affect child's
IQ
LONDON (Reuters) - Women who
drink even moderate amounts
of alcohol while pregnant may risk lowering child's intelligence levels, according to a study by
British scientists.
Advice to
pregnant women
about drinking is contradictory, with some guidelines recommending no alcohol
at all and others suggesting the odd drink now and then is safe. World
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But in a
study described as "hugely important" by one expert, researchers
using genetic analysis of more than 4,000 mothers and children found that
drinking between one and six units of alcohol a week during pregnancy can lead to
lower Intelligence Quotient
(IQ) scores by the time a child is eight.
"Even
at levels of alcohol
consumption which are normally considered to be harmless, we can
detect differences in childhood IQ which are dependent on the ability of the
fetus to clear this alcohol," said Sarah Lewis of Bristol University, who led
the study. "This is evidence that even at these moderate levels, alcohol
is influencing fetal brain development." World
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This
study used genetic data from women and children who were part of another study
called the Children of the 90s study.
Most
previous studies have used observational evidence, but experts say this can be
misleading because, for example, mothers who drink in moderation while pregnant
are typically also well educated, have good diets and are unlikely to smoke -
all factors linked to higher IQ in children and which could mask any negative
effects of alcohol. World
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A U.S.
study published in July found that older, educated women are more likely to
drink while pregnant.
GENES AFFECT ALCOHOL METABOLISMThis study, published in the journal PLOS ONE on Wednesday, used a new technique analyzing the genetic variants which modify the effects of alcohol exposure levels.
When a person drinks alcohol, ethanol is converted to acetaldehyde by a group of enzymes, the researchers explained.
Variations
in genes that 'encode' these enzymes lead to differences in a person's ability
to metabolize ethanol, so in "slow metabolizes", alcohol levels may
be higher for longer than in "fast metabolizes". Scientists think
fast ethanol metabolism protects against abnormal brain development because
less alcohol goes to the fetus.
The
mothers were asked to record their alcohol consumption at various stages during
pregnancy, and one drink was specified as one unit of alcohol. World
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The
results showed that four genetic variants in alcohol-metabolizing genes among
the 4,167 children were strongly related to lower IQ at age eight. The child's
IQ was on average almost two points lower per genetic variation they had.
"This is a complex study but the message is simple: even moderate amounts of alcohol during pregnancy can have an effect on future child intelligence." said Ron Gray of Oxford University, who was part of Lewis's team. World Hot Topics Blog
David
Nutt, a professor of neuropsychopharmacology at Imperial College London who was
not involved in the research, said it was "a hugely important study from
the best UK cohort that can study this question".
"Even
though the IQ effects are small, if at all possible women should avoid ethanol
in pregnancy as it's a known toxin," he said in an emailed comment.
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